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GNE-955
Product Name
GNE-955
CAS
1527523-39-2
MF
C22H24N8O
MW
416.48
EINECS
MOL File
1527523-39-2.mol
Chemical Properties
Boiling point
615.2±55.0 °C(Predicted)
Density
1.43±0.1 g/cm3(Predicted)
storage temp.
Store at -20°C
solubility
Soluble in DMSO
pka
9.90±0.20(Predicted)
Usage And Synthesis
Description
GNE-955 is a Potent Pan-Pim Inhibitor. GNE-955 is potent and has excellent bioavailability in rat.
Uses
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
IC 50
PIM1: 0.018 nM (Ki); PIM2: 0.11 nM (Ki); PIM3: 0.08 nM (Ki)
References
[1] Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60(10):4458-4473. DOI:
10.1021/acs.jmedchem.7b00418
GNE-955 Supplier
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +1-00000000000
Email
marketing@targetmol.com
GNE-955 manufacturers
GNE-955
Purity:
$3400.00
Inquiry
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