11-keto Fluprostenol is an analog of prostaglandin D
2 (PGD
2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF
2α and acts primarily through the FP receptor.
1 Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP
2 receptor compared to PGD
2 and essentially no activity at the DP
1 receptor.
2
1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α Nature 250(464),330-331(1974).
2. Monneret, G., Cossette, C., Gravel, S., et al. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils J. Pharmacol. Exp. Ther. 304(1),349-355(2003).
