t-boc-N-amido-PEG6-azide is a azide containing crosslinking reagent with a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The reagent can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.