2-NITRO-N-[[TRANS-4-[[[(1,2,3,4-TETRAHYDRO-2-NAPHTHALENYL)METHYL]AMINO]METHYL]CYCLOHEXYL]METHYL]BENZENESULFONAMIDE HYDROCHLORIDE

NTNCB Hydrochloride was used to study DNA encodoing a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5).

Selective, non-peptide competitive NPY Y 5 antagonist. K i values are 8.0 and 16032 nM at human recombinant Y 5 and Y 1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D 2 and α 2C receptors (K i values are 63 and 100 nM respectively).