Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via transcriptional activity. It also mediates cell responses to oxidative stress and treatment with antitumor agents. The expression of FOXO4 is repressed by microRNAs in multiple cancer cells, while FOXO4 function is regulated by post-translational modifications and interaction with other proteins. The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases[1].
[1] Wen Liu, Bing Luo, Yong Li. “Current perspective on the regulation of FOXO4 and its role in disease progression.” Cellular and Molecular Life Sciences 217 1 (2020): 651–663.
