MF 438

MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50= 2.3 nM.1MF-438 was potent in anin vivomouse liver PD assay (ED50between 1 and 3 mg/kg).1Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1].

[1] SERGE LÉGER. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 2: Pages 499-502. DOI:10.1016/j.bmcl.2009.11.111
[2] A NOTO. Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells[J]. Cell Death & Disease, 2013, 4 12: e947-e947. DOI:10.1038/cddis.2013.444
[3] N. RODRIGUEZ-PEREZ. Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma[J]. Allergy, 2017, 72 11: 1744-1752. DOI:10.1111/all.13180