CS-1305
CS-1305 性质
| 沸点 | 670.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.13±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥34mg/mL（65.54mM） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 16.21±0.70(Predicted) |
| 颜色 | 白色至米白色 |
CS-1305 用途与合成方法
Nrf2/ARE
CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).
CS-1305 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-12213 | 932730-51-3 | 1 mg | 950 | |
| 2026-09-15 | HY-12213 | CS-1305 | 932730-51-3 | 5mg | 2100 |
