5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-ylhydrosulfide

KKJ00626 is an inhibitor for Hepatitis B virus (HBV) with an IC50 of 0.12~0.23 μM. KKJ00626 inhibits the interaction between HBV core protein and the surface protein PreS region, prevents the maturation and secretion of HBV particles, and exhibits antiviral efficacy[1].

[1] Asif-Ullah M, et al., Identification of compounds that inhibit the interaction between core and surface protein of hepatitis B virus. Antiviral Res. 2006 Jun;70(2):85-90. DOI:10.1016/j.antiviral.2006.01.003