2-Chloro-5,6,7,8-tetrahydro-pyrido[3,4-d]pyriMidine

2-Chloro-5, 6, 7, 8-tetrahydro-pyrido [3, 4-d] pyrimidine is a deriviative of pyrimidine. 5, 6, 7, 8-tetrahydropyrido[3, 4-d] pyrimidine compounds can act as mTOR kinase and PI3 kinase inhibitors and be used in the treatment of related metabolic diseases. It can also inhibit the extracellular signal-regulated kinase (Erks), and thus have potential to assist in the treatment of related tumor.

https://www.mendeley.com/research-papers/5678tetrahydropyrido34dpyrimidine-compounds-mtor-kinase-pi3-kinase-inhibitors-preparation-treatment/
Blake, J. F., et al. "Discovery of 5, 6, 7, 8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. " Bioorganic & Medicinal Chemistry Letters 24.12(2014):2635-2639.