Ethanone, 2-bromo-1-cyclopropyl-

765-43-5

69267-75-0

The general procedure for the synthesis of 1-cyclopropyl-2-bromoacetophenone from cyclopropylmethyl ketone was as follows: a methanol (MeOH, 100 mL) solution of cyclopropylmethyl ketone (20.7 mL, 220 mmol) was treated with bromine (11.3 mL, 220 mmol) at -5 °C and the reaction lasted for 2 hours. Subsequently, 50 mL of water was added to the reaction mixture and the reaction system was slowly warmed to room temperature and left to stand overnight. After completion of the reaction, the mixture was diluted with 150 mL of water and extracted with ether. The organic phase was separated, washed with sodium bicarbonate (NaHCO3) solution, dried over anhydrous sodium sulfate (Na2SO4), and concentrated to remove the solvent to give the light yellow oily product 1-cyclopropyl-2-bromoacetophenone (35 g, 99% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 0.91-1.02 (m, 2H), 1.03-1.16 (m, 2H), 2.08-2.20 (m, 1H), 4.02 (s, 2H).