PSD95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses. Recent work suggests that interaction of the NMDAR with PSD95 via these PDZ domains can be regulated by phosphorylation.
