4-(Isopropylamino)butanol

13325-10-5

67-64-1

42042-71-7

The general procedure for the synthesis of 4-(isopropylamino)butanol from 4-amino-1-butanol and acetone was as follows: 200 g of 4-amino-1-butanol (II) was dissolved in a solvent mixture of 400 ml of acetone and 1,000 ml of ethanol, to which was added 20 g of 10% Pd/C catalyst. The hydrogenation reaction was carried out at a hydrogen pressure of 10 atmospheres for 4 to 5 hours. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was subsequently concentrated to afford the target compound 4-(isopropylamino)butanol as a colorless oil in quantitative yield.