二乙酸贝毒素
中文名称:二乙酸贝毒素
英文名称:SAXITOXIN
CAS号:35523-89-8
分子式:C10H17N7O4
分子量:299.29
EINECS号:
Mol文件:35523-89-8.mol
二乙酸贝毒素 性质
| 沸点 | 440.62°C (rough estimate) |
|---|---|
| 密度 | 1.3010 (rough estimate) |
| 折射率 | 1.6400 (estimate) |
| 储存条件 | −20°C |
| 酸度系数(pKa) | 13.32±0.50(Predicted) |
| 旋光度 (Optical Rotation) | +13320 (H2O) |
| EPA化学物质信息 | Saxitoxin (35523-89-8) |
二乙酸贝毒素 用途与合成方法
用途
Mussel poison; clam poison; paralytic shellfish poison; gonyaulax toxin. These poisonous shellfish have been connected to instances of toxic鈥漴ed-tides’where the high concentration of algae discolorin
g the water were of the Gonyaulax genus.
Used as a tool in neurochemical research. 类别
有毒物质 毒性分级
剧毒 急性毒性
口服- 大鼠 LD50 0.192 毫克/ 公斤; 口服- 小鼠 LD50: 0.263 毫克/公斤 可燃性危险特性
可燃;火场释放有毒氮氧化物烟雾 储运特性
库房低温, 通风, 干燥; 与食品原料分开存放 灭火剂
水, 二氧化碳, 泡沫, 砂土 安全信息
| 危险品标志 | T+ |
|---|---|
| 危险类别码 | 26/27/28 |
| 安全说明 | 36/37/39-45 |
| 危险品运输编号 | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| 毒性 | During seasons when dinoflagellates “bloom,” filter-feeding shellfish become contaminated with accumulated toxin and are toxic when eaten. STX blocks nerve membrane sodium channels in nanomolar concentrations when applied externally. STX competes with tetrodotoxin (TTX) for binding to sodium channels. The mechanism of action on nerves is the same as that of TTX, although recovery from STX block occurs slightly faster than that after TTX block. The i.p. LD50 in mice is 10 μg/kg. Symptoms in humans within 30 min of ingestion include tingling and burning in face, lips, tongue, and eventually the whole body, parathesia followed by numbness, ataxia, general motor incoordination, confusion, and headache. Death due to respiratory paralysis occurs within 12 h. Treatment is restricted to symptoms. There is no antidote, and emesis is advisable. Artificial respiration is given if neces_x0002_sary. Prostigmine methylsulfate (1 mL of 1:2000 solution, i.v.) is helpful. |
