beta-Phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate, SP-isomer sodium salt

Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system[1].

[1] Barnstable, Colin J., Ji-Ye Wei, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochemistry international 45.6 (2004): 875-884. DOI:10.1016/j.neuint.2004.03.018