BREVETOXIN PBTX-3
BREVETOXIN PBTX-3 性质
| 密度 | 1.190±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20C |
| 溶解度 | DMSO：可溶，乙醇：可溶，甲醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.78±0.70(Predicted) |
| 颜色 | 白色至米白色 |
BREVETOXIN PBTX-3 用途与合成方法
IC50: voltage-gated Na + channel
Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV).
Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues. .
| Animal Model: | Pregnant CD-1 mice |
| Dosage: | 2.8 μg/kg |
| Administration: | Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 |
| Result: | Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure. |
