GP ANTAGONIST-2A

[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

Cell permeable: no', 'Primary Target
Inhibits the activation of Gq by M1-muscarinic cholinergic receptors', 'Product does not compete with ATP.', 'Reversible: no

[1] Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104. DOI:10.1016/0014-2999(85)90529-1
[2] Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243. PMID:1379592