Citrullinated vimentin (G147R) (R145 + R147) (140-160)-biotin peptide is a biotinylated version of a di-citrullinated form of a mutant isoform of the cytoskeleton intermediate filament protein vimentin, vimentinG146R, which has been found in the synovial fluid of patients with rheumatoid arthritis.1 Vimentin is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) under high calcium concentrations, which can occur during macrophage apoptosis.2,3 Serum levels of immune complexes targeting citrullinated vimentin are increased in patients with rheumatoid arthritis and positive for anti-citrullinated protein antibodies (ACPAs).4 Serum and plasma levels of citrullinated vimentin are also increased in patients with lung cancer or idiopathic pulmonary fibrosis, respectively.5,6 Cayman’s Citrullinated Vimentin (G147R) (R145 + R147) (140-160)-biotin Peptide is intended for use in the detection of autoantibodies against vimentinG146R citrullinated at R145 and R147.WARNING This product is not for human or veterinary use.
