Norbixin (hydrate)

Norbixin is a carotenoid that has been found in B. orellana and has diverse biological activities.1,2,3,4 It binds to peroxisome proliferator-activated receptor γ (PPARγ) in a cell-free assay (Ki = 1.15 µM).1 Norbixin (47.7 mg/kg) attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome. It decreases serum levels of oxidized LDL and aortic protein oxidation, as well as reduces atherosclerotic area, in a rabbit model of cholesterol-induced atherosclerosis.2 Norbixin (0.1 and 1 mg/kg per day) reduces mercury-induced DNA damage in isolated rat hepatocytes and leukocytes.3 It also prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of age-related macular degeneration (AMD).4WARNING This product is not for human or veterinary use.

[1] ROHINI A. . Norbixin, an apocarotenoid derivative activates PPARγ in cardiometabolic syndrome: Validation by in silico and in vivo experimental assessment[J]. Life sciences, 2018, 209: Pages 69-77. DOI: 10.1016/j.lfs.2018.08.001
[2] SABRINA SOMACAL . Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation[J]. Food Research International, 2022, 159: Article 111522. DOI: 10.1016/j.foodres.2022.111522
[3] GUSTAVO RAFAEL MAZZARON BARCELOS. Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo[J]. Environmental and Molecular Mutagenesis, 2012, 53 7: 535-541. DOI: 10.1002/em.21715
[4] VALÉRIE FONTAINE. Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.[J]. Aging-Us, 2020, 12 7: 6151-6171. DOI: 10.18632/aging.103014