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(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE

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(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Basic information
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Chemical Properties
Safety Information
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE Usage And Synthesis
  • OccurrenceAn oily alkaloid, anatoxin-a has been isolated from Anabaena jfos-aquae.
  • Uses(+)-Anatoxin-a is a secondary, bicyclic amine alkaloid and cyanotoxin with acute neurotoxicity. The toxin is produced by at least four different genera of cyanobacteria and has been reported in North America, Europe, Africa, Asia, and New Zealand. Symptoms of anatoxin exposure are loss of coordination, muscular fasciculations, convulsions and death by respiratory paralysis.
  • Synthesis Reference(s)Journal of the American Chemical Society, 106, p. 4539, 1984 DOI: 10.1021/ja00328a040
  • Biological ActivityA potent nicotinic agonist (K i values are 1.25 and 1840 nM for α 4 β 2 and α 7 nicotinic receptors respectively). Stimulates [ 3 H]-dopamine release from rat striatal synaptosomes (EC 50 = 136 nM).
  • Safety ProfilePoison by intraperitoneal route.An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.
(+/-)-2-ACETYL-9-AZA BICYCLO[4.2.1]NON-2-ENE FUMARATE(64285-06-9)Related Product Information
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