锦菊素 性质
| 熔点 | 180-182 °C(Solv: acetone (67-64-1); dichloromethane (75-09-2)) |
|---|---|
| 沸点 | 466.6±45.0 °C(Predicted) |
| 密度 | 1.22±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
锦菊素 用途与合成方法
锦菊素提取自旋复花，可用作活性小分子。 Bigelovin 是可从海百合中分离得到的一种倍半萜内酯，是选择性的视黄素 X 受体 α (retinoid X receptor α) 的激动剂。Bigelovin 可通过诱导凋亡和自噬来发挥抗肿瘤活性。Bigelovin 通过抑制 ROS 的生成来调节 mTOR 信号通路。
Bigelovin (0-20 μM, 24-72 h) significantly inhibits cell viability of liver cancer cells and induces apoptosis and autophagy.
Bigelovin causes a significant increase of p62, LC3B-II, Beclin-1 and a corresponding decrease of p62 levels in a time-dependent manner.
Bigelovin induces cell death involves the suppression of mTOR pathway regulated by ROS production.
Cell Viability Assay
| Cell Line: | HepG2 and SMMC-7721 cells. |
| Concentration: | 0-20 μM. |
| Incubation Time: | 24, 48, 72 h. |
| Result: |
Significantly reduced the cell viability of HepG2 and SMMC-7721 cells in a dose- and time
dependent manner.
No significant difference observed in cell viability of normal liver cell lines, LO2 and LX2, after BigV treatment for 24, 48 or 72 h. |
Western Blot Analysis
| Cell Line: | HepG2 and SMMC-7721 cells. |
| Concentration: | 0-10 μM. |
| Incubation Time: | 24 h. |
| Result: |
The expression of Bcl-2 was decreased, whereas Bax was increased after treatment with BigV. Moreover, Caspase-9, -3 and PARP cleavage were activated significantly after BigV treatment.
|
Bigelovin (BigV, 5, 10, 20 mg/kg) exerts anti-tumor activity in HepG2 xenograft tumor model.
| Animal Model: | HepG2 xenograft model based on the male athymic BALB/c nude mice (5-6 weeks old, 18-22 g). |
| Dosage: | 5, 10, 20 mg/kg. |
| Administration: | Intravenous injection every 2 days. |
| Result: |
The tumor growth rate was significantly slower in BigV treated groups in a dose-dependent manner, along with the reduced tumor weight.
No significant alteration of body weight and hepatic enzyme levels (AST, ALT and LDH) in serum was observed after BigV administration. Western blot findings of tumor tissues indicated the activation of apoptosis and autophagy characterized by the increase of cleaved Caspase-3 and PARP, as well as LC3BII levels. The inactivation of mTOR was also observed in tumor tissues isolated from BigV-treated mice. |
锦菊素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-116506 | 锦菊素 | 3668-14-2 | 5mg | 2800 |
| 2024-11-08 | HY-116506 | 锦菊素 | 3668-14-2 | 10mg | 3700 |
锦菊素供应商 更多
成都普瑞法科技开发有限公司
联系电话：+86-028-82633397 18982077548
产品介绍：
中文名称：锦菊素
英文名称：Bigelovin
CAS：3668-14-2
纯度：>95%,98%,99%
包装信息：From mgs to grams,up to Kgs.Inquire for Bulk scale.
备注：可以大量定制
四川省维克奇生物科技有限公司
联系电话：028-81700200 18116577057
产品介绍：
中文名称：锦菊素
英文名称：Bigelovin
CAS：3668-14-2
纯度：98%
包装信息：5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
上海瀚香生物科技有限公司
联系电话：17754423994 17754423994
产品介绍：
中文名称：锦菊素
英文名称：Bigelovin
CAS：3668-14-2
纯度：98% HPLC LCMS
包装信息：500mg;1g;10g
备注：量大优惠，现货促销
北京普西唐生物科技有限公司
联系电话：010-60605840 18892239720
产品介绍：
英文名称：Bigelovin
CAS：3668-14-2
纯度：98%(HPLC)
包装信息：5mg
备注：分析标准品
成都普思生物科技股份有限公司
联系电话：028-85370565-229 18080489829
产品介绍：
中文名称：锦菊素
英文名称：Bigelovin
CAS：3668-14-2
纯度：95%
包装信息：10mg
备注：面议询价
