tolmetin glucuronide

Tolmetin β-D-glucuronide is a major phase II metabolite of tolmetin . Tolmetin β-D-glucuronide has been classified into a ‘warning’ category in terms of its potential to cause idiosyncratic drug toxicity, based on its half-life in several in vitro systems.

Beige Solid

A metabolite of Tolmetin.

ChEBI: Tolmetin glucuronide is a glucosiduronic acid.

[1] MARTHA L. HYNECK . High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1987, 420: Pages 349-356. DOI: 10.1016/0378-4347(87)80190-1
[2] RYOKO SAWAMURA. Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide.[J]. Drug Metabolism and Disposition, 2010, 38 10: 1857-1864. DOI: 10.1124/dmd.110.034173