LF 1695 is a synthetic immunomodulator.
LF 1695 is an immunomodulator. LF 1695 enhances the proliferative response of T cells by increasing the production of IL2 (interleukin-2) or the expression of the IL2 receptor. LF 1695 also increases CONA-induced inhibitory activity in human lymphocytes. LF 1695 can be used to study the proliferative and inhibitory activity of T cell subpopulations, as well as their role in immune regulation[1].
This was further confirmed by the fact that LF 1695 inhibited the second wave of platelet aggregation induced by ADP as well as arachidonic acid effects. Incubation of platelets with [14C]arachidonic acid in the presence of 60 microM LF 1695 resulted in a strong inhibition of arachidonic acid incorporation into the various cell lipids, indicating that arachidonic acid mobilization might be due to inhibition of reacylation processes._x000D_
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Reference: Biochem Pharmacol. 1989 Sep 1;38(17):2763-72. https://pubmed.ncbi.nlm.nih.gov/2505775/
CBA, H2k mice receiving a lethal dose of irradiation were injected with spleen cells from LF 1695-treated or untreated C57 Bl/6, H2b mice via different routes. Mice treated intraperitoneally with LF 1695 at 2.5 or 5 mg/kg/day showed an increase of GvHR intensity with splenic index of 1.71 and 1.80, respectively. When the animals were treated continuously through drinking water containing LF 1695 (4 mg/kg, 10 mg/kg or 100 mg/kg), these ratios were: 1.82, 1.10 and 1.37, respectively. Finally, LF 1695 enhanced GvHR significantly when used at low doses, while high doses induced a decrease of GvHR intensity._x000D_
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Reference: Int J Immunopharmacol. 1991;13(5):599-604. https://pubmed.ncbi.nlm.nih.gov/1838358/
LF 1695 is a synthetic immunomodulator.
[1] Othmane O, et al. A new immunomodulator, LF 1695—I. in vitro effects on the T lymphocyte lineage in man[J]. International journal of immunopharmacology, 1985, 7(4): 543-548. DOI:
10.1016/0192-0561(85)90074-8
