101189-47-3
中文名称:101189-47-3
英文名称:2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
CAS号:101189-47-3
分子式:C13H20N6S
分子量:292.4
EINECS号:
Mol文件:101189-47-3.mol
101189-47-3 性质
沸点 | 517.0±42.0 °C(Predicted) |
---|---|
密度 | 1.34±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 11.38±0.10(Predicted) |
101189-47-3 用途与合成方法
CP-66948 是 histamine H2 受体拮抗剂,能够抑制胃酸分泌,保护粘膜的作用。
The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED 50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED 50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED 50 values of 12 mg/kg per os and 6 mg/kg subcutaneously).
101189-47-3供应商 更多
上海德轩医药科技有限公司
联系电话: 1701086315
产品介绍:
英文名称:101189-47-3
CAS:101189-47-3
纯度:99% HPLC
包装信息:1G;5G;10G;100G;1KG;
备注:医药级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 T15005
英文名称:CP-66948;CP66948,CP 66948
CAS:101189-47-3
纯度:98%
包装信息:5 mg