(S)-3,4-Dihydroxybutyric acid is a normal human urinary metabolite that is excreted in increased concentration in patients with succinic semialdehyde dehydrogenase (SSADH) deficiency.
ChEBI: 3S,4-dihydroxy-butyric acid is a 3-hydroxy carboxylic acid.
3,4-Dihydroxybutyric acid is a normal human urinary metabolite th at is excreted in increased concentration in patients with succinic semialdehyde dehydro- genase (SSADH) deficiency, while healthy adults excrete 0.37 +/- 0.15 (SD) mmoles of 3,4- dihydroxybutyrate per 24 hr. The renal clearance of this compound is roughly equal th at of creatinine. This metabolite is also detectable in blood.
Human Endogenous Metabolite
[1] Shinka T, et al. Rapid and sensitive detection of urinary 4-hydroxybutyric acid and its related compounds by gas chromatography-mass spectrometry in a patient with succinic semialdehyde dehydrogenase deficiency. J Chromatogr B Analyt Technol Biomed Life S DOI:
10.1016/s1570-0232(02)00126-5
