3,4-dihydroxy-Butanoic acid

Product Name3,4-dihydroxy-Butanoic acid
CAS51267-44-8
MFC4H8O4
MW120.1
EINECS
MOL File51267-44-8.mol

Chemical Properties

Boiling point	408.9±35.0 °C(Predicted)
Density	1.420±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	solid
pka	4.27±0.10(Predicted)
optical activity	[α]/D -25±5°, 24hr, c =0.1 in 0.1 M HCl

Usage And Synthesis

Uses

(S)-3,4-Dihydroxybutyric acid is a normal human urinary metabolite that is excreted in increased concentration in patients with succinic semialdehyde dehydrogenase (SSADH) deficiency.

Definition

ChEBI: 3S,4-dihydroxy-butyric acid is a 3-hydroxy carboxylic acid.

Biological Activity

3,4-Dihydroxybutyric acid is a normal human urinary metabolite th at is excreted in increased concentration in patients with succinic semialdehyde dehydro- genase (SSADH) deficiency, while healthy adults excrete 0.37 +/- 0.15 (SD) mmoles of 3,4- dihydroxybutyrate per 24 hr. The renal clearance of this compound is roughly equal th at of creatinine. This metabolite is also detectable in blood.

IC 50

Human Endogenous Metabolite

References

[1] Shinka T, et al. Rapid and sensitive detection of urinary 4-hydroxybutyric acid and its related compounds by gas chromatography-mass spectrometry in a patient with succinic semialdehyde dehydrogenase deficiency. J Chromatogr B Analyt Technol Biomed Life S DOI:10.1016/s1570-0232(02)00126-5