Crystagen, a tripeptide, has been shown to inhibit the proliferation of embryonic mesenchymal stem cells and to enhance the proliferative activity of blood lymphocytes in adults. Crystagen also caused a restoration in the cell content of the main subpopulations of the immune system upon high exercise stress. Moreover, it induced the proliferation of NK cells and promoted the increased expression of the CD3 immature Tcell marker. Crystagen activates B-cells of the immune system. However, the peptide doesn't cause cell renewal in the spleen as it ages[1–2].
[1] N. Chervyakova. “Age-related molecular aspects of immunomodulating activity of peptides in the spleen.” Advances in Gerontology 4 1 (2014): 12–15.
[2] N A Сhervyakova. “[Molecular aspects of immunoprotective activity of peptides in spleen during the ageing process].” Advances in gerontology = Uspekhi gerontologii 27 1 (2014): 224–228.
