MBD2 binds to methylated DNA in vitro or in vivo, suggesting th at MBD2 targets the MeCP1 complex to methylated DNA. MBD2a interacts with RNA Helicase A (RHA). MBD2 protein appear to protect against some cancers.', 'Methyl-CpG binding domain protein 2 (MBD2a) acts as a repressor during transcription.