PEROXYNITRITE

Peroxynitrite has been used to induce pericyte contraction in mouse brains. It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.

Peroxynitrite (ONOO-) exhibits bactericidal activity. It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.