Retin-20,20,20-d3-ol, 15-acetate

Product NameRetin-20,20,20-d3-ol, 15-acetate
CAS118139-36-9
MFC22H32O2
MW328.5
EINECS
MOL File118139-36-9.mol

Usage And Synthesis

Description

ALK-001 is a vitamin A analog potentially for the treatment of Stargardt’s disease.

Uses

Retinyl acetate-d3 (ALK-001) is a deuterated Vitamin A. Retinyl acetate-d3 can be used for research of geographic atrophy (GA) secondary to age-related macular degeneration (AMD)[1].

References

[1] Cargnin S, et al. A primer of deuterium in drug design. Future Med Chem. 2019 Aug;11(16):2039-2042. DOI:10.4155/fmc-2019-0183
[2] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110