cGAMP disodium

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions[1][2].

Human Endogenous Metabolite

Store at -20°C

[1] Wright TA, et al. Second messengers and divergent HD - GYP phosphodiesterases regulate 3’,3’ - cGAMP signaling. Mol Microbiol. 2020;113(1):222 - 236.
[2] BRYAN W DAVIES. Coordinated regulation of accessory genetic elements produces cyclic di - nucleotides for V. cholerae virulence.[J]. Cell, 2012, 149 2: 358 - 370. DOI: 10.1016/j.cell.2012.01.053
[3] XU ZHANG. Cyclic GMP - AMP containing mixed phosphodiester linkages is an endogenous high - affinity ligand for STING.[J]. Molecular Cell, 2013, 51 2: 226 - 235. DOI: 10.1016/j.molcel.2013.05.022