Wogonoside (80 mg/kg, oral gavage, once every other day) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic model[3].
Wogonoside (40 or 80 mg/kg, i.p., every three days) inhibits tumor growth and reduces Bcl-2/Bax ratio in A549 cell xenograft mice[4].
Wogonoside (80 mg/kg, i.P., every other day for 14 days) also inhibits tumor growth in U937 xenograft model[5].
| Animal Model: | MDA-MB-231 orthotopic model[3] |
| Dosage: | 80 mg/kg |
| Administration: | oral gavage, once every other day |
| Result: | Inhibited tumor growth (46%) and metastasis in brain, lung, liver and bone.
Increased the expression of E-cadherin and reduced the expression of MMP-9, vimentin and Twist1 at orthotopic site. |
