3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
英文名称:3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester
CAS号:544450-68-2
分子式:C16H16ClNO3S
分子量:337.82
EINECS号:
Mol文件:544450-68-2.mol
![3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester 结构式](https://img.chemicalbook.com/CAS/20200611/GIF/544450-68-2.gif)
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester 性质
| 储存条件 | 4°C, away from moisture and light |
|---|---|
| 溶解度 | 二甲基亚砜：33.33 mg/mL（98.66 mM） |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester 用途与合成方法
COR659 是有效的 GABAB 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。
COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA B receptor and an action at the cannabinoid CB1 receptor.
COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.
COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.
| Animal Model: | Male sP and Wistar rats. |
| Dosage: | 0, 2.5, 5 and 10 mg/kg. |
| Administration: | Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.). |
| Result: |
The magnitude of the reducing effect of the compound on number oflever-responses for alcohol averaged approximately 30, 55, and 70%, in comparison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively. |
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-137204 | 2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯 | 544450-68-2 | 5mg | 2400 |
| 2024-04-30 | HY-137204 | 2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯 | 544450-68-2 | 10mM * 1mLin DMSO | 2640 |
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester供应商 更多
上海睿升化工科技有限公司
联系电话： 15026594951
产品介绍：
英文名称：COR659
CAS：544450-68-2
纯度：97% HPLC
包装信息：1g;5g
备注：现货 黄色粉末
合肥钼凯医药科技有限公司
联系电话： 18130062233
产品介绍：
中文名称：2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯
英文名称：Methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate
CAS：544450-68-2
纯度：97%
包装信息：5g25g100g
上海毕得医药科技股份有限公司
联系电话：400-1647117 15221909166
产品介绍：
中文名称：2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯
英文名称：Methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate
CAS：544450-68-2
纯度：98%
包装信息：100mg;250mg;1g
备注：BD01293839
TargetMol中国（陶术生物）
联系电话： 4008200310
产品介绍：
中文名称：化合物COR659
英文名称：COR659;COR 659,Gamma-aminobutyric acid Receptor,sucrose,inhibit,chocolate,γ-Aminobutyric acid Receptor,GABA Receptor,COR-659,Inhibitor,COR659,alcohol
CAS：544450-68-2
纯度：99.56%
包装信息：1 mg;1 mL;10 mg;100 mg;25 mg;5 mg;50 mg
