N-(t-butyl ester-PEG2)-N-bis(PEG3-azide) is a branched conjugation reagent The azide groups is very reactive with alkyne such as DBCO, BCN and propargyl reagnet via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound.
N-(Boc-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Boc-PEG2)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
