N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)

N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a 3-arm PEG reagentr consisting of a terminal azide group and two t-butyl esters. The azide group enables PEGylation via Click Chemistry. The t-buty ester groups can be hydrolyzed under mild acidic conditions.

N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

PEGs; Alkyl/ether

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005