TEMOCILLIN

Product NameTEMOCILLIN
CAS61545-06-0
MFC16H18N2O7S2
MW414.45
EINECS262-835-9
MOL File61545-06-0.mol

Chemical Properties

storage temp.	-20°C, stored under nitrogen
form	Solid
color	Off-white to yellow
Water Solubility	Water : 250 mg/mL (545.35 mM; Need ultrasonic)

Usage And Synthesis

Uses

Temocillin Disodium is the salt of Temocillin, which is a β-lactam stable against most β-lactamases is used as an alternative to carbapenems.

Definition

ChEBI: Temocillin disodium is an organic sodium salt. It contains a temocillin(2-).

Biological Activity

Temocillin Disodium inhibits bacterial cell wall synthesis, which is necessary for the growth and survival of bacterial cells. Specifically, it interferes with the synthesis of peptidoglycan, the major component of the bacterial cell wall, by binding to a specific target on the cell wall synthesis enzyme called penicillin-binding protein 3 (PBP3). This blocks the synthesis of peptidoglycan, leading to the weakening and eventual lysis of the bacterial cell.

in vivo

Temocillin dosing regimens of 200 mg/kg every 4 and 6 h remained significantly effective in reducing bacterial titres in kidneys against the two strains, with no significant difference between the parental strain and its transconjugant^[2].