ALBORIXIN

Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease[1].

ChEBI: A polyether antibiotic that is isolated from cultures of a strain of Streptomyces albus.

[1] Wani A, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019 Oct;15(10):1810-1828. DOI:10.1080/15548627.2019.1596476
[2] C DELHOMME. Alborixin, a new antibiotic ionophore: taxonomy, isolation and biological properties.[J]. Journal of Antibiotics, 1976, 29 7: 692-695. DOI: 10.7164/antibiotics.29.692
[3] AABID MANZOOR SHAH . Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells[J]. Chemico-Biological Interactions, 2016, 256: Pages 198-208. DOI: 10.1016/j.cbi.2016.06.032
[4] N MOINS  P D M  P Gachon. Effects of two monocarboxylic ionophores, grisorixin and alborixin, on cardiovascular function and plasma cation concentrations in the anesthetized dog.[J]. Journal of Cardiovascular Pharmacology, 1979, 1 6: 659-671. DOI: 10.1097/00005344-197911000-00007
[5] B L BLAGBURN. Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.[J]. Antimicrobial Agents and Chemotherapy, 1991, 35 7: 1520-1523. DOI: 10.1128/aac.35.7.1520