右旋达尔丰
中文名称:右旋达尔丰
英文名称:Propoxyphene
CAS号:469-62-5
分子式:C22H29NO2
分子量:339.48
EINECS号:207-420-5
Mol文件:469-62-5.mol
右旋达尔丰 性质
| 熔点 | 75-76° |
|---|---|
| 比旋光度 | D25 +67.3° (c = 0.6 in chloroform) |
| 沸点 | 475.43°C (rough estimate) |
| 密度 | 1.0751 (rough estimate) |
| 折射率 | 1.5614 (estimate) |
| 闪点 | 2℃ |
| 储存条件 | 2-8°C |
| 酸度系数(pKa) | pKa 6.3(50% aq EtOH) (Uncertain) |
| Henry's Law Constant | 4.3×103 mol/(m3Pa) at 25℃, HSDB (2015) |
| EPA化学物质信息 | Propoxyphene (469-62-5) |
安全信息
| 危险品标志 | F,Xn,T |
|---|---|
| 危险类别码 | 11-20/21/22-36-52/53-25 |
| 安全说明 | 16-26-36/37-61-45-36/37/39 |
| 危险品运输编号 | 3249 |
| WGK Germany | 2 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 毒害物质数据 | 469-62-5(Hazardous Substances Data) |
| 毒性 | An opioid analgesic similar in structure to methadone. It is a much less potent analgesic than morphine and is devoid of antipyretic or anti-inflammatory effects. Its side effects are qualitatively similar to codeine. The clinical indications for propoxyphene are much the same as for aspirin. It is used when the degree of analgesia required is less than that produced by morphine. Recent clinical trials suggest that propoxyphene is no more effective in controlling mild pain than is aspirin. Because they act by different mechanisms, aspirin and propoxyphene have often been given in combination. Recently, there has been a trend away from use of propoxyphene because its weak analgesic properties do not compensate for other problems with its use. Interestingly, the analgesic activity of propoxyphene resides largely in the dextrorotatory isomer, whereas the antitussive effect is produced primarily by the levorotatory isomer. The use of propoxyphene was banned in the United States in November 2010. The oral LD50 in rats is 84 mg/kg. |
