3-Ethoxysalicylaldehyde

3-ethoxysalicylaldehyde is also known as o-ethyl vanillin. 3-ethoxysalicylaldehyde often appears as a by-product in the production process of ethyl vanillin, which gradually becomes an alternative to vanillin since it possesses a flavor and odor approximately 3 ～ 4 times as intense as vanillin. In recent years, it has been discovered that 3-ethoxysalicylaldehyde possesses potential applications in optical utilization, biology, catalysis, and corrosion inhibition. Moreover, 3-ethoxysalicyaldehyde has been applied in various medicinal applications[1].

3-Ethoxysalicylaldehyde was used in the preparation of:

• Schiff base ligand via condensation with trans-1,2-diaminocyclohexane
• substituted salen-type Schiff base ligands
• a new Schiff base, 2-ethoxy-6-[(3-methylaminopropylimino)methyl]phenol, via reaction with N-methylpropane-1,3-diamine

A poison by intraperitoneal andintravenous routes. When heated to decomposition itemits acrid smoke and irritating vapors.

[1] Haifang Mao . “Solubility measurement and data correlation of 3-ethoxysalicylaldehyde in twelve pure solvents at temperatures from 278.15 to 313.15 K.” Journal of Chemical Thermodynamics 188 (2023): Article 107162.