This not naturally occurring amino acid was first observed after alkali treatment of different proteins. Synthetic lysinoalanine was found to have a strong chelating ability for metals. For a complete survey of our special amino acids please ask for our information sheet BA 060 Special Amino Acids and Amino Acid Derivatives. Lit. J.C.Woodward et al.; Food Cosmet. Toxicol. 15, 109 (1977)/ R.Hayashi; J. Biol. Chem. 257, 13896 (1982)
Lysinoalanine Dihydrochloride (cas# 4418-81-9) can be synthesized from alkali-treated wool. This not naturally occurring amino acid was first observed after alkali treatment of different proteins. Synthetic Lysinoalanine was found to have a strong chelating ability for metals.
This nephrotoxic amino acid analogue (FW = 233.27 g/mol), also known as lysinoalanine, is also a metal ion chelator. This property demands the experimenter to carry out measurements at a constant free metal ion concentration to differentiate enzyme inhibition effects from metal ion chelation effects. Target(s): lysyl-tRNA synthetase; carboxypeptidase A; carboxypeptidase B; alcohol dehydrogenase, yeast; cytochrome c oxidase.
