A-317491 (0.1-30 mg/kg; a single s.c.) dose-dependently reverses inflammatory mechanical hyperalgesia in rats[2].
A-317491 (3-30 mg/kg; a single .v.) exhibits the plasma half-life (7.38 h), clearance rate (1.83 L/h/kg), and volume of distribution (0.17 L/kg)[2].
| Animal Model: | Male adult Sprague-Dawley rats received an intraplantar injection of Freund's complete adjuvant[2] |
| Dosage: | 0.1, 1, 3, 10, 30 mg/kg |
| Administration: | A single s.c. |
| Result: | Produced a dose-dependent reduction in mechanical hyperalgesia 1 h, 3 h and 5 h post-administration. |
