化合物 T28017
化合物 T28017 性质
| 密度 | 1.51±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>5mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | -2.16±0.20(Predicted) |
| 颜色 | 粉红至紫色 |
| InChI | 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18) |
| InChIKey | GFYRZTLCYQQVHZ-UHFFFAOYSA-N |
| SMILES | Sc1nc(c(c(n1)O)C(=O)Nc2ccccc2)O |
化合物 T28017 用途与合成方法
topoisomerase II
Merbarone (1-100 μM) inhibits L1210 cells proliferation in a concentration-dependent manner, with an IC
50
of 10 μM.
Merbarone (10-200 μM; 10 min) inhibits DNA relaxation catalyzed by human topoisomerase IIα, with an IC
50
of ∼40 μM.
Merbarone (25-200 μM; 6 min) blocks tyopoisomerase II-mediated DNA cleavage, with an IC
50
of ∼50 μM.
Merbarone (100 μM; 6 min) inhibits topoisomerase II-mediated DNA cleavage in a global manner.
Merbarone (100 μM; 6 min) does not impair topoisomerase II•DNA binding.
Merbarone (200 μM; 4-16 min) does not inhibit topoisomerase II-catalyzed ATP hydrolysis.
Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia.
Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice.
化合物 T28017 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-19024 | 化合物 T28017 | 97534-21-9 | 5mg | 550 |
| 2026-09-15 | HY-19024 | 化合物 T28017 | 97534-21-9 | 10 mM * 1 mLin DMSO | 605 |
