t-Boc-Aminooxy-PEG1-amine

t-Boc-Aminooxy-PEG1-amine is a PEG linker containing a Boc-protected aminooxy group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.