t-Boc-Aminooxy-PEG3-azide is a click chemistry reagent containing a t-Boc-aminooxy group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The protected aminooxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.