N-(acid-PEG3)-N-bis(PEG3-azide)

Product NameN-(acid-PEG3)-N-bis(PEG3-azide)
CAS2182602-17-9
MFC25H49N7O11
MW623.71
EINECS
MOL File2182602-17-9.mol

Chemical Properties

storage temp.	Storage temp. -20°C
solubility	Soluble in Water, DMSO, DCM, DMF
form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Description

N-(acid-PEG3)-N-bis(PEG3-azide) is a a-arm PEGylation reagent with azide moieties and a terminal carboxylic acid. The azide groups enable Click Chemistry. PEG linker increases the solubility of the compound in aqueous media.

Uses

N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(acid-PEG3)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005