Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Diagnostic agents >  Organ Function Test agent >  PENTAGASTRIN


Basic information Safety Related Supplier
PENTAGASTRIN Basic information
PENTAGASTRIN Chemical Properties
  • Melting point:229-230° (dec)
  • alpha D22 -28.8 ±0.5° (DMF)
  • Boiling point:1196.6±65.0 °C(Predicted)
  • Density 1.303±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
  • form powder
  • pka4.19±0.10(Predicted)
Safety Information
PENTAGASTRIN Usage And Synthesis
  • Chemical PropertiesA white or almost white powder.
  • OriginatorPeptavlon,I.C.I. ,UK,1967
  • Usesanesthetic (local)
  • Usesdiagnostic agent for gastric secretion disorders
  • Manufacturing ProcessA solution of 3.55 parts of L-tryptophanyl-L-methionyl-L-aspartyl-Lphenylalanine amide trifluoroacetate in 30 parts of dimethylformamide is cooled to 0°C, and 1.01 parts of triethylamine are added. The mixture is stirred while 1.84 parts of N-tert-butyloxycarbonyl-β-alanine 2,4,5trichlorophenyI ester are added at 0°C. The reaction mixture is kept at 0°C for 48 hours and then at 20°-23°C for 24 hours. The mixture is added to a mixture of 100 parts of ice-water, 0.37 part of concentrated hydrochloric acid (SG 1.18), 1.2 parts of acetic acid and 20 parts of ethyl acetate. The mixture is stirred for 15 minutes at 0°-10°C and is then filtered. The solid residue is washed with water and then with ethyl acetate, and is dried at 40°-50°C under reduced pressure. There is thus obtained N-tert-butyloxycarbonyl-βalanyl-L-tryptophanyl-L-methionyl-L-aspartyl-L-phenylalanine amide, MP 213°C with de composition.
  • brand namePeptavlon (Wyeth).
  • Therapeutic FunctionGastrosecretory hormone
  • General DescriptionPentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
    Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.
PENTAGASTRIN Preparation Products And Raw materials
PENTAGASTRIN(5534-95-2)Related Product Information
  • Company Name:Avantpbc Chemical Tech(Shanghai) Co,Ltd. Gold
  • Tel:17802107445
  • Email:
  • Company Name:Hangzhou Peptidego Biotech Co.,Ltd. Gold
  • Tel:0571-87213919-
  • Company Name:GL Biochem (Shanghai) Ltd
  • Tel:13641803416 21-61263452-
  • Company Name:LGM Pharma
  • Tel:1-(800)-881-8210
  • Company Name:Nanjing Chemlin Chemical Co., Ltd
  • Tel:025-83697070