D-Ala-Gly-Phe-Met-NH2 monoacetate, an opioid peptide, is a potent opiate δ-receptor agonist[1].
in vivo
D-Ala-Gly-Phe-Met-NH2 monoacetate (7.1 nM and 14.2 nM (0.5 μL); microinjection; male Sprague-Dawley rats) increases ethanol intake in preference to food in the nucleus accumbens (NAc)[1].
Animal Model:
Male Sprague-Dawley rats (200-250 g)[1]
Dosage:
7.1 nM and 14.2 nM (0.5 μL)
Administration:
Microinjection in the nucleus accumbens (NAc)
Result:
Increased ethanol intake in the nucleus accumbens (NAc).
References
[1] Barson JR, et, al. Opioids in the nucleus accumbens stimulate ethanol intake. Physiol Behav. 2009 Oct 19;98(4):453-9. DOI:10.1016/j.physbeh.2009.07.012
