Valnemulin (100 mg/kg, i.g., single dose) exhibits lung protectiv effects in LPS-induced acute lung injury in BALB/c mice[2].
Valnemulin hydrochloride (10 mg/kg, p.o.; 10 days) has a control effect in experimental infection of calves with Mycoplasma bovis, and can effectively eliminate Mycobacterium bovis in the lungs [3].
| Animal Model: | Lipopolysaccharide induced acute lung injury in BALB/c mice[2]. |
| Dosage: | 100 mg/kg |
| Administration: | i.g., single dose |
| Result: | Reduced levels of neutrophils, lymphocytes and macrophages, and expressions of TNF-α, IL-6, and IL-1β in bronchoalveolar lavage fluid (BALF).
Increased superoxidase dismutase (SOD) activity in BALF, decreased myeloperoxidase (MAO) activity in lung. |
| Animal Model: | Mycoplasma bovis infection treated male calves aged 10-35 days[3] |
| Dosage: | 10 mg/kg |
| Administration: | p.o., 10 days |
| Result: | Resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss.
Effectively reduced the isolation of Pasteurella multocida from the calves, lungs.
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