玫瑰树碱盐酸盐
玫瑰树碱盐酸盐 性质
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
---|---|
溶解度 | DMSO:4.4(最大浓度 mg/mL);15.56(最大浓度 mM) |
形态 | 结晶固体 |
颜色 | 浅黄至黄色 |
玫瑰树碱盐酸盐 用途与合成方法
Target | Value |
P450
() | |
peroxidase
() | |
Topo II
() |
Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.
Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).
玫瑰树碱盐酸盐 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | S6790 | 玫瑰树碱盐酸盐 | 5081-48-1 | 5mg | 587.68 |
2024-11-08 | S6790 | 玫瑰树碱盐酸盐 | 5081-48-1 | 25mg | 1970 |