基本属性 生物活性靶点体外研究体内研究 用途与合成方法 玫瑰树碱盐酸盐 价格(试剂级) 供应商 供应信息 相关产品
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玫瑰树碱盐酸盐

玫瑰树碱盐酸盐

英文名称:Ellipticine (hydrochloride)
CAS号:5081-48-1
分子式:C17H15ClN2
分子量:282.77
EINECS号:
Mol文件:5081-48-1.mol
玫瑰树碱盐酸盐 结构式

玫瑰树碱盐酸盐 性质

储存条件 Inert atmosphere,Store in freezer, under -20°C
溶解度 DMSO:4.4(最大浓度 mg/mL);15.56(最大浓度 mM)
形态 结晶固体
颜色 浅黄至黄色

玫瑰树碱盐酸盐 用途与合成方法

Ellipticine Hydrochloride (NSC 71795, PZE)是一种有效的 DNA topoisomerase II 的抑制剂,并通过其与 cytochromes P450 (CYP) 和 peroxidases 的氧化作用介导形成共价DNA加合物。Ellipticine Hydrochloride 是从澳大利亚的夹竹桃科常绿乔木中分离出来的具有抗肿瘤活性的天然产物。
TargetValue
P450
()
peroxidase
()
Topo II
()

Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.

Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).

玫瑰树碱盐酸盐 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 S6790 玫瑰树碱盐酸盐 5081-48-1 5mg 587.68
2024-11-08 S6790 玫瑰树碱盐酸盐 5081-48-1 25mg 1970

玫瑰树碱盐酸盐供应商 更多

上海芮晖化工科技有限公司
现货
联系电话:21-31433387 15618786686
产品介绍:
英文名称:Ellipticine hydrochloride(NSC 71795 hydrochloride)
CAS:5081-48-1
纯度:98% HPLC
包装信息:50mg;100mg;1g;5g
备注:原料级
库存量:>1g
现货日期:2024/12/18 10:22:19
四川省维克奇生物科技有限公司
联系电话:028-81700200 18116577057
产品介绍:
中文名称:玫瑰树碱盐酸盐
英文名称:Ellipticinehydrochloride
CAS:5081-48-1
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg;500mg;1g
上海源叶生物科技有限公司
联系电话:021-61312847; 18021002903
产品介绍:
英文名称:Ellipticine (hydrochloride)
CAS:5081-48-1
纯度:98%
包装信息:5mg;10mg;50mg;100mg;2mg;25mg
备注:生化试剂
上海瀚香生物科技有限公司
联系电话:177-54423994 17754423994
产品介绍:
中文名称:玫瑰树盐酸盐
英文名称:Ellipticine Hydrochloride
CAS:5081-48-1
纯度:98% HPLC LCMS
包装信息:100mg;500mg;1g;5g;10g
备注:量大优惠,现货促销
上海超岚化工科技中心
联系电话:021-QQ:65489617 15618227136
产品介绍:
中文名称:Ellipticine hydrochloride盐酸盐
英文名称:Ellipticine hydrochloride
CAS:5081-48-1
纯度:98%
包装信息:5MG;10MG;50MG;100MG,1G,5G,100G

最新发布供应信息

玫瑰树碱盐酸盐|T4614|TargetMol
TargetMol中国(陶术生物) 2024-12-12
玫瑰树碱盐酸盐
台州市科瑞生物技术有限公司 2024-12-11

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