1825355-56-3
1825355-56-3 性质
| 沸点 | 672.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥ 24.6 mg/mL（58.64 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.44±0.50(Predicted) |
| 颜色 | 白色至米白色 |
1825355-56-3 用途与合成方法
Bacterial riboflavin riboswitches
Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli . Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli , Pseudomonas aeruginosa , and Acinetobacter baumannii , to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth.
Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log 10 [CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed.
1825355-56-3 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-19488A | 1825355-56-3 | 1825355-56-3 | 5mg | 900 |
| 2024-11-08 | HY-19488A | 1825355-56-3 | 1825355-56-3 | 10mM * 1mLin DMSO | 990 |
