m-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
IC 50
PEGs; Cleavable Linker
References
[1] Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1. [2] Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1.
