ML346
ML346 性质
| 熔点 | 266-268 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| 密度 | 1.374±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO溶解度：8.0(最大浓度 mg/mL);29.38(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 7.42±0.20(Predicted) |
| 颜色 | 粉红至红色 |
ML346 用途与合成方法
| Target | Value |
|
HSP70
() |
ML346 is an activator of Hsp70, with an EC 50 of 4600 nM in HeLa cells. ML346 (10 μM) restores proteostasis, restores CFTR-mediated iodide conductance, and enhances the correct folding of proteins expressed in two different cellular compartments. ML346 (Compound F1) induces multiple responses and strongly induces Hsp70, the oxidative stress response genes (HO1 and GCLM), and a 2.5-fold upregulation of BiP in WT MEF cells. ML346 (0.5-25 μM) exhibits cytoprotective effects in cells after a 35 min severe heat shock, and also causes a two-fold protection from H 2 O 2 -induced apoptosis.
ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity.
ML346 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-18669 | ML346 | 100872-83-1 | 2mg | 600 |
| 2024-11-08 | HY-18669 | ML346 | 100872-83-1 | 10mM * 1mLin DMSO | 898 |
